It increases your skin's sensitivity to ultraviolet (UV) rays, which can lead to sunburn and irritation; applying the cream at night reduces the exposure to harmful UV radiation.

Tretinoin can degrade when exposed to sunlight, compromising its effectiveness; applying the cream at night ensures the product remains stable and can work effectively to promote cell turnover and skin renewal.

Nighttime application allows for enhanced absorption, as the product can work uninterrupted by makeup, sunscreen, or other daytime products. This allows for maximal benefits of improving skin texture, reducing fine lines, and treating acne.

Skin tends to be less exposed to environmental pollutants and irritants at night, providing a controlled environment that reduces the risk of irritation.

Please note: To protect your skin during the day, it’s crucial to use a broad-spectrum SPF as part of your morning skincare routine; this will help shield your skin from UV damage and complement the nighttime benefits of tretinoin.