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Pellet Therapy Compared to HRT Patches, Creams, and Pills

Learn the differences between pellet therapy and other forms of hormone replacement therapy, including patches, creams and pills.

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Written by Patient_Care
Updated this week

What is pellet therapy?

Pellet therapy is a form of hormone replacement therapy (HRT) that involves surgically inserting hormone pellets under the skin. Pellets last around 3-5 months, and the procedure must be repeated for as long as therapy is desired. Note: Winona does not prescribe pellet therapy.

Benefits of pellet therapy:

  • Sustained, consistent release of hormones over time

  • Can use bioidentical hormones

  • Can combine multiple hormones in one pellet

Drawbacks of pellet therapy:

  • Invasive surgical procedure with risks of bruising, bleeding, or infection

  • Requires in-person doctor visits every 3-5 months

  • Irreversible once inserted

  • Limited ability to adjust doses or correct unwanted side effects

  • Less preferred for those with sensitive skin

What are HRT patches, creams, and pills?

HRT is also available in other forms, including patches, creams, and pills. Winona prescribes each of these methods in personalized doses.

Patches: Applied to the skin and changed 1-2 times per week

Pills: Taken orally, usually daily

Creams: Applied to the skin, typically daily

Benefits of patches, pills, and creams:

  • Sustained, consistent release of hormones over time

  • Can use bioidentical hormones

  • Creams: Can combine multiple hormones in one cream

  • Non-invasive application, no surgical risks

  • Easy to personalize, reverse, or adjust doses

  • No in-person visits required

  • Simple, familiar application methods

Drawbacks of patches, pills and creams:

  • Require more frequent dosing

  • Patches and creams: less preferred for those with sensitive skin

  • Pills: less preferred for those with liver conditions

Why does Winona prescribe patches, creams, and pills, but not pellets?

Winona focuses on personalized, convenient care. Our prescribing philosophy is to improve symptoms with minimal risks and discomfort. For these reasons, Winona prescribes patches, creams, or pills. These treatments can be applied from the comfort of home, have more customization and adjustment options, and best prevent unwanted effects or discomfort.

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