Winona's hormone replacement options include creams, patches, and pills. All of these treatment methods are effective, so the method of delivery is a personal preference between each patient and their doctor.

Some women prefer to take pills, because of the convenience. Other women choose the cream or patch to better fit their lifestyle. These transdermal options bypass the liver, which can make it easier on your system, but all of the methods are viable and safe options.

Creams are a means of transdermal dosing, meaning the medication is absorbed through the skin’s layers and deposited into the bloodstream. This method of delivery bypasses the gastrointestinal tract, more quickly distributing the medication throughout the body. Dosing through the skin bypasses the liver and is generally considered to be easier on the body, because a lower dose is required.

Capsules and tablets are taken daily, like other pills or supplements. They are filtered through the liver, which breaks down a significant portion of the hormones. To account for this, the dosages of hormones in oral delivery methods are higher than those of transdermal options. Winona’s estrogen comes in vegan tablets, while the progesterone and DHEA come in capsules that contain gelatin.

Estrogen patches are small, sticker-like adhesives designed to allow for direct skin absorption and the gradual and controlled release of hormones into the bloodstream. This form of transdermal dosing bypasses the liver's initial metabolism, resulting in a lower required dosage compared to oral medications. The patch is easy to apply and provides a convenient way to receive hormone therapy without the need for daily administration.